EC Number   |
Metals/Ions |
Reference |
|---|
   3.4.21.6 | Ca2+ |
- |
650193, 652501 |
| 3.4.21.6 | Ca2+ |
absolutely required for activity as part of the prothrombinase complex |
652682 |
| 3.4.21.6 | Ca2+ |
activates |
717253 |
| 3.4.21.6 | Ca2+ |
Ca2+-dependent binding of factor Xa to e.g. phospholipids |
683178 |
| 3.4.21.6 | Ca2+ |
dependent on |
731389 |
| 3.4.21.6 | Ca2+ |
dependent on, cooperative binding, required of the intact enzyme and also of its Gla-domain and EGF-like domain to interact with negatively charged phospholipids containing 25% phosphatidylserine and 75% phosphatidylcholine, 3 Ca2+ per binding partner |
651123 |
| 3.4.21.6 | Ca2+ |
dependent on, required for coordination of the enzyme domains, residues Asp46, Gly47, Gln49, and Gly64 are involved in Ca2+ binding, modeling of the calcium-binding site within the serine protease domain |
650582 |
| 3.4.21.6 | Ca2+ |
factor Xa forms the prothrombin-converting complex with factor V, phospholipid and Ca2+ |
81417, 81420 |
| 3.4.21.6 | Ca2+ |
ion binding site structure, overview |
683252 |
| 3.4.21.6 | Ca2+ |
required |
650164, 650179, 650585, 717829, 717968, 718415 |
