EC Number   |
Metals/Ions |
Reference |
|---|
   3.4.21.21 | Ca2+ |
- |
669484, 670270, 683139, 683298, 683996 |
| 3.4.21.21 | Ca2+ |
5 mM used in assay conditions |
754382 |
| 3.4.21.21 | Ca2+ |
activates |
683347 |
| 3.4.21.21 | Ca2+ |
binding structure |
683477 |
| 3.4.21.21 | Ca2+ |
bound to the backbone-carbonyl groups of Asp72 and Glu75, and to the side-chain carboxylate groups of Glu70 and Glu80 |
656505 |
| 3.4.21.21 | Ca2+ |
Ca2+ ions constitute an important cofactor for FVIIa and bind to a total of nine sites, seven in the N-terminal gamma-carboxyglutamic acid (Gla) domain and one each in the first EGF-like and protease domains |
710606 |
| 3.4.21.21 | Ca2+ |
dependent on, eight Ca2+ are bound via the Gla domain and involved in enzyme binding to the membrane with different tasks, structure and coordination, mechanism of Ca2+-mediated binding, overview |
684070 |
| 3.4.21.21 | Ca2+ |
one FVIIa molecule binds 8 Ca2+ in the epidermal growth factor-like and the gamma-carboxyglutamic acid-rich domains |
683855 |
| 3.4.21.21 | Ca2+ |
required |
754202 |
| 3.4.21.21 | Ca2+ |
the enzyme binds the phospholipid membrane in a Ca2+-dependent manner. Ca2+ ions are required for assembly and function of the tissue factor-enzyme complex |
755547 |
