EC Number |
Metals/Ions |
Reference |
---|
2.7.1.158 | Mg2+ |
dependent on |
660942 |
2.7.1.158 | Mg2+ |
included in assay medium |
686761 |
2.7.1.158 | Mg2+ |
maximal activity at 4 mM |
662093 |
2.7.1.158 | Mg2+ |
optimal concentration is 10 mM |
662106 |
2.7.1.158 | Mg2+ |
required |
760240, 760326, 760534, 761238, 761460, 761678, 762144, 762323 |
2.7.1.158 | Mg2+ |
required, binding structure, overview |
761763 |
2.7.1.158 | Zn2+ |
mammalian IP5 2-Ks share a zinc-binding site with a distinct structure. Murine mIP5 2-K presents two zinc ions in its structure, one in the CIP-lobe (Zn1) and the other close to the hinge region (Zn2), binding structure, overview. The Zn1 site is formed by residues from two CIP lobe elements: Cys159, Cys162, and Cys181 from CIP-I and Cys291 from CIP-II. This site presents the typical zinc geometry and coordination. Zn1 is necessary for protein folding and stability |
761460 |