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EC Number
Metals/Ions
Commentary
Reference
2.4.1.90
Ca2+
10 mM used in assay conditions
757639
2.4.1.90
Ca2+
about 50% of the activity with Mn2+
489555
2.4.1.90
Ca2+
active only with mutant enzymes M334H and M344E, no activity with wild-type enzyme and mutants M344A, M344S, and M344Q
658032
2.4.1.90
Ca2+
can partially replace Mn2+
489493
2.4.1.90
Ca2+
slight activation
660309
2.4.1.90
Co2+
activates, not as effective as Mn2+
660309
2.4.1.90
Co2+
activation at 14.9% of the activity with Mn2+
489526
2.4.1.90
Co2+
less active than Mn2+ with wild-type and mutant enzymes
658032
2.4.1.90
Fe2+
no activation
489555
2.4.1.90
Fe2+
partial activation
489555
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