EC Number |
Metals/Ions |
Reference |
---|
2.4.1.221 | Ca2+ |
2fold increase at 10 mM |
441440 |
2.4.1.221 | Ca2+ |
activates, but less effectiv than Mg2+ and Mn2+ |
722118 |
2.4.1.221 | Mg2+ |
activates |
722118 |
2.4.1.221 | Mn2+ |
10fold increase at 50 mM, 4fold increase at 10 mM |
441440 |
2.4.1.221 | Mn2+ |
17fold increase at 50 mM |
441442 |
2.4.1.221 | Mn2+ |
activates transfer of fucose from DP-fucose to small EGF repeats |
723541 |
2.4.1.221 | Mn2+ |
activates wild-type and mutant enzymes, but has a nonessential role in catalysis. Residue R290 replaces Mn2+ function by establishing electrostatic and hydrogen bond interactions with beta-phosphate |
736861 |
2.4.1.221 | Mn2+ |
activates, but less effectiv than Mg2+ |
722118 |
2.4.1.221 | more |
Mg2+ is not required for catalytic activity by POFUT1, glycosyltransferases adopting GT-B folds are metal-independent |
723541 |