EC Number |
Metals/Ions |
Reference |
---|
2.3.2.5 | Ca2+ |
contains a calcium ion |
720244 |
2.3.2.5 | Co2+ |
enzyme inactivated by 1,10-phenanthroline or dipicolinic acid can be restored partially by Co2+ or Mn2+ |
659288 |
2.3.2.5 | Mn2+ |
enzyme inactivated by 1,10-phenanthroline or dipicolinic acid can be restored partially by Co2+ or Mn2+ |
659288 |
2.3.2.5 | more |
human glutaminyl cyclase and bacterial zinc aminopeptidase share a common fold and active site. Glutaminyl cyclase does not appear to require zinc for enzymatic activity |
658350 |
2.3.2.5 | more |
substrate specificity for substrates with uncharged backbone and for Gln-Ala and Gln-Glu, does not change significantly by salt addition. With the positively charged substrates Gln-Arg-Gly-Ile-NH2 and Gln-Lys-Arg-Leu-NH2 addition of salt reveals a positive effect on catalysis |
658233 |
2.3.2.5 | more |
substrate specificity for substrates with uncharged backbone does not change significantly by salt addition. For substrates such as Gln-Ala and Gln-Glu, addition of KCl decreases specificity. With the positively charged substrates Gln-Arg-Gly-Ile-NH2 and Gln-Lys-Arg-Leu-NH2 addition of salt reveals a positive effect on catalysis |
658233 |
2.3.2.5 | more |
the enzyme is metal-independent |
735370 |
2.3.2.5 | Zinc |
contains one zinc ion per protein molecule |
660450 |
2.3.2.5 | Zinc |
stoichiometric amounts of zinc bound to protein. Depletion of zinc has no significant effect on protein structure, metal has a catalytic role |
671982 |
2.3.2.5 | Zn |
equimolar protein-bound zinc |
685085 |