EC Number   |
Metals/Ions |
Reference |
|---|
   1.6.3.1 | Ba2+ |
very low activity |
636496 |
| 1.6.3.1 | Ca2+ |
- |
674466 |
| 1.6.3.1 | Ca2+ |
a Ca2+/NADPH-dependent H2O2 generating system is associated with isoform Duox2 protein expression |
671214 |
| 1.6.3.1 | Ca2+ |
activates |
741954 |
| 1.6.3.1 | Ca2+ |
an increase in cytosolic calcium concentration triggers high superoxide production by Nox5. Calcium induces binding of the N-terminal domain of Nox5 to the dehydrogenase domain, thus relieving autoinhibition. Two mechanisms may increase Nox5 sensitivity, allowing activation by resting calcium concentrations: (1) calcium-dependent binding of calmodulin to another site in the dehydrogenase domain157 and (2) phosphorylation of serine and threonine residues by protein kinase C and calcium/calmodulin-dependent kinase II |
724778 |
| 1.6.3.1 | Ca2+ |
Ca2+ may regulate the interaction between cytosolic regulator subunit Rac and the N-terminal extension of the catalytic subunit in a dynamic manner |
689468 |
| 1.6.3.1 | Ca2+ |
Ca2+-induced conformation change of NADPH oxidase 5 N-terminus leads to enzyme activation through an intramolecular interaction |
659332 |
| 1.6.3.1 | Ca2+ |
generation of H2O2 by transfected isoform Duox2 depends on Ca2+ |
674466 |
| 1.6.3.1 | Ca2+ |
half maximal activity with 0.0001 mM Ca2+ |
636496 |
| 1.6.3.1 | Ca2+ |
no activity without |
636493 |
