EC Number |
Metals/Ions |
Reference |
---|
1.14.15.6 | Mg2+ |
- |
285413 |
1.14.15.6 | Fe2+ |
a cytochrome P450 enzyme |
687970 |
1.14.15.6 | Fe2+ |
cytochrome P450 enzyme |
688147 |
1.14.15.6 | Fe2+ |
heme iron |
675689, 702781 |
1.14.15.6 | more |
increase of side chain cleavage activity from 50 to 100 mM NaCl, higher concentrations cause a decrease, total loss at 300 mM |
285414 |
1.14.15.6 | Mg2+ |
increased MgCl2 concentrations continue to increase side chain cleavage activity even after all adrenodoxin is reduced |
285414 |
1.14.15.6 | Ca2+ |
increased rate of association of cholesterol to partially purified cytochrome P-450scc |
285417 |
1.14.15.6 | Ca2+ |
ineffective activator |
285414 |
1.14.15.6 | more |
Kd for adrenodoxin increases with increase of ions from NaCl, binding of adrenodoxin to P-450scc is more sensitive to changes in metal ion concentration than cholesterol binding, high salt concentrations cause fall-off in activity |
285413 |
1.14.15.6 | Ca2+ |
particulary but also other metal ions modulate adrenodoxin binding to adrenodoxin reductase and P-450, therefore activation of cholesterol side chain cleavage and adrenodoxin reduction |
285414 |