EC Number |
Metals/Ions |
Reference |
---|
1.11.1.9 | Ba2+ |
2 mM, 147% of initial activity |
764056 |
1.11.1.9 | Ca2+ |
2 mM, 150% of initial activity |
764056 |
1.11.1.9 | cadmium |
in liver, by 24 h, exposure to alow dose of Cd causes 13% loss of Gpx4a expression. At higher dose, Cd leads to 40% decrease in Gpx4a expression. Longer exposure periods cause about 20% loss of liver Gpx4a expression by low Cd dose |
724102 |
1.11.1.9 | cadmium |
olfactory isoform Gpx4b mRNA expression is not extensively modulated by presence of cadmium ions. In liver, by 24 h, exposure to alow dose of Cd causes 18% loss of Gpx4b expression. At higher dose, Cd leads to 37% decrease in Gpx4b expression. Longer exposure periods cause about 22% loss of liver Gpx4b expression by low Cd dose, whereas at higher Cd exposures, a 33% loss in Gpx4b expression is observed |
724102 |
1.11.1.9 | Co2+ |
2 mM, 184% of initial activity |
764056 |
1.11.1.9 | Mg2+ |
2 mM, 154% of initial activity |
764056 |
1.11.1.9 | Mn2+ |
221% relative activity |
396642 |
1.11.1.9 | more |
induction of cellular selenium-dependent glutathione peroxidase activity: 2.2fold by 0.015 mM Na2SeO3, 1.9fold by 0.1 mM Na2SeO4, 4.3fold by 0.03 mM L-selenocystine. 4.6fold by 0.1 mM L-selenocystine,2-oxoselenazolidine-4(R)-carboxylic acid, 1.4fold by 0.1 mM D-selenocystine,2-oxoselenazolidine-4(R)-carboxylic acid, 2.1fold by 0.1 mM L-selenocystine,2-(RS)-methylselenazolidine-4(R)-carboxylic acid, 1.3fold by 0.1 mM D-L-selenocystine,2-(RS)-methylselenazolidine-4(R)-carboxylic acid, 5.9fold by 0.1 mM L-selenoproline, 1.5fold by Se-methyl-L-selenocysteine, 1.8fold by L-selenomethionine |
659677 |
1.11.1.9 | more |
not inhibitory: 3 M NaCl |
742024 |
1.11.1.9 | more |
selenium, zinc and tellurium have no stimulatory effect on glutathione peroxidase |
685480 |