EC Number   |
Metals/Ions |
Reference |
|---|
   3.4.22.53 | Ca2+ |
absolute requirement |
644025 |
| 3.4.22.53 | Ca2+ |
activated by Ca2+ |
732365 |
| 3.4.22.53 | Ca2+ |
activates |
644026, 717806 |
| 3.4.22.53 | Ca2+ |
activates. The results support the hypothesis that Ca2+ induces movement of domains I and II closer together to form the functional active site of calpain |
644017 |
| 3.4.22.53 | Ca2+ |
best activator at 2.5 mM, maximal caseinolytic activity at 2.2 mM, half-maximal caseinolytic activity at 0.312 mM |
644052 |
| 3.4.22.53 | Ca2+ |
Ca2+ induces calpain translocation to the membrane during ischemia |
709566 |
| 3.4.22.53 | Ca2+ |
Ca2+-binding must induce conformational changes that reorient the protease domains to form a functional active site |
644020 |
| 3.4.22.53 | Ca2+ |
Ca2+-induced calpain translocation to the membrane during ischemia is independent of its activation |
709566 |
| 3.4.22.53 | Ca2+ |
calcium-dependent cysteine protease |
708416 |
| 3.4.22.53 | Ca2+ |
calpain 2 is activated with addition of CaCl+ to 1 mM |
709126 |
