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EC Number	Metals/Ions	Commentary	Reference
3.4.22.52	Ca2+	half-maximal activation at 0.03 mM, maximal activation at 0.1 mM	643980
3.4.22.52	Ca2+	dimeric calpain I requires 0.002 mM for half-maximal activation and 0.01 mM for maximal activation. The 70000 Da monomeric calpain I requires only 0.001 mM Ca2+ for half-maximal activity	643981
3.4.22.52	Ca2+	half-maximal activation at 0.008 mM, maximal activation at 0.02 mM	643982
3.4.22.52	Ca2+	half-maximal activation at 0.0028 mM, maximal activation at 0.01 mM	643983
3.4.22.52	Ca2+	half-maximal activation at 0.01 mM	643986
3.4.22.52	Ba2+	activates	643987
3.4.22.52	Ca2+	-	643983, 643987, 696451
3.4.22.52	Ca2+	half-maximal activation at 0.002 mM, full activity at 0.01 mM	643987
3.4.22.52	Mn2+	activates	643987
3.4.22.52	Sr2+	activates	643987

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Release 2023.1 (January 2023)