EC Number   |
Metals/Ions  |
Reference |
|---|
   3.4.22.52 | Ca2+ |
calcium-dependent cysteine protease |
708416 |
| 3.4.22.52 | Ca2+ |
calcium-dependent, increase of amount of bound calpain 1 by calcium binding to titin |
696290 |
| 3.4.22.52 | Ca2+ |
calpain 1 is activated by micromolar calcium concentrations |
717053 |
| 3.4.22.52 | Ca2+ |
calpain I is a calcium-dependent protease |
708434 |
| 3.4.22.52 | Ca2+ |
calpain1 is a calcium ion-dependent cysteine protease |
707296 |
| 3.4.22.52 | Ca2+ |
dependent on |
707936, 708442, 708717, 708892, 709640, 710087, 717453, 718111, 718386, 731222, 731848, 731906, 752801 |
| 3.4.22.52 | Ca2+ |
dependent on (0.002-0.02 mM). At resting [Ca2+], mu-calpain is present predominantly in its full-length, unautolysed/unactivated forms. Once activated, mu-calpain appears in its autolysed form. Endogenously expressed mu-calpain is activated within a physiological [Ca2+] range in a Ca2+- and time-dependent manner. Autolysed mu-calpain isoforms have a greater Ca2+ sensitivity than the full-length 80000 Da isoform |
708194 |
| 3.4.22.52 | Ca2+ |
dependent on, 100% activity at concentrations higher than 0.04 mM |
732676 |
| 3.4.22.52 | Ca2+ |
dependent on, dysfunctional mitochondria increase cytosolic calcium, thereby inducing calpain activation |
710069 |
| 3.4.22.52 | Ca2+ |
dimeric calpain I requires 0.002 mM for half-maximal activation and 0.01 mM for maximal activation. The 70000 Da monomeric calpain I requires only 0.001 mM Ca2+ for half-maximal activity |
643981 |
