EC Number   |
Localization |
GeneOntology No. |
Reference |
|---|
   3.4.22.61 | cytoplasm |
- |
GO:0005737 AmiGO QuickGO |
698197 |
| 3.4.22.61 | cytoplasm |
caspase-8/cullin-3/p62 complex is translocates to the cytosol from where it induces apoptosis in a p62-dependent manner |
GO:0005737 AmiGO QuickGO |
717276 |
| 3.4.22.61 | cytosol |
- |
GO:0005829 AmiGO QuickGO |
-, 647432, 663939, 680898, 695523, 696138, 697175, 697284, 698328, 731601, 754897 |
| 3.4.22.61 | cytosol |
mature caspase-8 is released into cytosol. The signaling complex containing p62 and polyubiquitinated active caspase-8 translocates to cytosol to form the proapoptotic speckle called as aggresome to induce cell apoptosis in a p62-dependent manner |
GO:0005829 AmiGO QuickGO |
717900 |
| 3.4.22.61 | lamellipodium |
in addition to its cytosolic distribution, caspase 8 is recruited to lamella of migrating cells |
GO:0030027 AmiGO QuickGO |
680898 |
| 3.4.22.61 | lipid raft |
- |
- |
664679 |
| 3.4.22.61 | membrane |
lipid rafts |
GO:0016020 AmiGO QuickGO |
700899 |
| 3.4.22.61 | membrane |
procaspase-8 is part of the trans-plasma membrane death-inducing signaling complex and is located on the cytosolic side. The activated enzyme is then released from the complex as caspase-8 |
GO:0016020 AmiGO QuickGO |
717605 |
| 3.4.22.61 | mitochondrion |
- |
GO:0005739 AmiGO QuickGO |
664711, 664969, 666402, 666515, 717470 |
| 3.4.22.61 | mitochondrion |
the mitochondrial membrane protein Cardif plays a role in caspase-8 translocation to mitochondria. The anionic mitochondria-specific phospho-lipid cardiolipin acts as a mitochondria-associated platform that is actually required for caspase-8 translocation in type II cells |
GO:0005739 AmiGO QuickGO |
717276 |
