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EC Number Localization Commentary GeneOntology No. Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.2.1.166cell surface - GO:0009986 AmiGO QuickGO 731867, 732546
Display the word mapDisplay the reaction diagram Show all sequences 3.2.1.166cell surface HPSE can be trafficked to the cell surface or released into the extracellular matrix in order to effect breakdown of extracellular pools of heparan sulfate GO:0009986 AmiGO QuickGO 754873
Display the word mapDisplay the reaction diagram Show all sequences 3.2.1.166cell surface the signal peptide sequence accounts for the chicken heparanase being readily secreted and localized in close proximity to the cell surface GO:0009986 AmiGO QuickGO 692954
Display the word mapDisplay the reaction diagram Show all sequences 3.2.1.166cytoplasm - GO:0005737 AmiGO QuickGO 731350, 731867
Display the word mapDisplay the reaction diagram Show all sequences 3.2.1.166endosome late GO:0005768 AmiGO QuickGO 754873
Display the word mapDisplay the reaction diagram Show all sequences 3.2.1.166endosome late endosomes GO:0005768 AmiGO QuickGO 753404
Display the word mapDisplay the reaction diagram Show all sequences 3.2.1.166extracellular heparanase is the only known mammalian endoglycosidase capable of degrading heparan sulfate glycosaminoglycan, both in extracellular space and within the cells - 732436
Display the word mapDisplay the reaction diagram Show all sequences 3.2.1.166extracellular heparanase-1 is mostly an intracellular, lysosomal enzyme. Only in cases where the receptor-system is absent or defective, the enzyme accumulates extracellularly. The presence of extracellular (active) heparanase-1 seems to be tightly regulated and restricted by at least two independent mechanisms, on one hand by regulated secretion and on the other hand by lipoprotein receptor-related proteins mediated (re-)uptake - 693320
Display the word mapDisplay the reaction diagram Show all sequences 3.2.1.166extracellular HPSE can be trafficked to the cell surface or released into the extracellular matrix in order to effect breakdown of extracellular pools of heparan sulfate - 754873
Display the word mapDisplay the reaction diagram Show all sequences 3.2.1.166extracellular the enzyme is secreted in invasive cells such as inflammatory cells and highly migratory tumor cells - 731648
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