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EC Number
Localization
Commentary
GeneOntology No.
Reference
3.1.1.64
cytosol
-
GO:0005829
AmiGO
QuickGO
170636
,
714020
,
714986
,
714991
3.1.1.64
cytosol
about 30% of total enzyme is found in the cytosol
GO:0005829
AmiGO
QuickGO
680672
3.1.1.64
cytosol
the ratio of cytosolic to microsomal RPE65 is approximately 1:2
GO:0005829
AmiGO
QuickGO
706574
3.1.1.64
cytosol
wild type RPE65 is present at a lower level in the cytosolic fraction
GO:0005829
AmiGO
QuickGO
714020
3.1.1.64
endoplasmic reticulum
-
GO:0005783
AmiGO
QuickGO
679833
3.1.1.64
membrane
-
GO:0016020
AmiGO
QuickGO
714150
,
714161
,
714951
,
714986
,
714991
,
715473
,
715501
,
715577
,
716114
3.1.1.64
membrane
membrane association of RPE65 is essential for its catalytic activity. The RPE65 membrane-binding affinity is significantly facilitated by incorporation of its substrate all-trans retinyl ester into liposomal membrane
GO:0016020
AmiGO
QuickGO
714103
3.1.1.64
membrane
microsome
GO:0016020
AmiGO
QuickGO
704711
,
706574
3.1.1.64
membrane
microsone
GO:0016020
AmiGO
QuickGO
706518
3.1.1.64
membrane
Rpe65 is strongly associated with membranes but contains no membrane-spanning segments
GO:0016020
AmiGO
QuickGO
715577
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