EC Number   |
Localization |
GeneOntology No. |
Reference |
|---|
    2.3.1.23 | cytoplasm |
Prdx6 is a unique LPCAT enzyme with demonstrated cytoplasmic localization |
GO:0005737 AmiGO QuickGO |
-, 757372 |
| 2.3.1.23 | cytosol |
- |
GO:0005829 AmiGO QuickGO |
486622 |
| 2.3.1.23 | endoplasmic reticulum |
- |
GO:0005783 AmiGO QuickGO |
-, 486644, 687802, 719936, 736479 |
| 2.3.1.23 | endoplasmic reticulum |
associated with |
GO:0005783 AmiGO QuickGO |
659434 |
| 2.3.1.23 | endoplasmic reticulum membrane |
- |
GO:0005789 AmiGO QuickGO |
675007 |
| 2.3.1.23 | Golgi membrane |
associated |
GO:0000139 AmiGO QuickGO |
675007 |
| 2.3.1.23 | Golgi membrane |
associated with, catalytic domain of the enzyme is exposed to the cytosol rather than to lumen of the Golgi cisternae |
GO:0000139 AmiGO QuickGO |
657761 |
| 2.3.1.23 | Golgi membrane |
Golgi membrane tubule formation can result from increasing the content of lysophospholipids in membranes, either by stimulation of a phospholipase A2 or by inhibition of an lysophosphatidylcholine acyltransferase. The two opposing enzyme activities may help to coordinately regulate Golgi membrane shape and tubule formation |
GO:0000139 AmiGO QuickGO |
659908 |
| 2.3.1.23 | lamellar body |
- |
GO:0042599 AmiGO QuickGO |
-, 757372 |
| 2.3.1.23 | lipid droplet |
in addition to endoplasmic reticulum, both isoforms LCAT1 and LCAT2 localize to lipid droplets, which consist of a core of neutral lipids surrounded by a monolayer of phospholipid, mainly phosphatidylcholine. This dual localization is enabled by the monotopic topology of the enzymes with both termini facing the cytoplasm, irrespective of supplementation with oleic acid. Lipid droplets have the ability to locally synthesize phosphatidylcholine and this activity correlates with the LPCAT1 and -2 expression levels |
GO:0005811 AmiGO QuickGO |
719936 |
