EC Number |
Recommended Name |
Localization |
GeneOntology No. |
Reference |
---|
1.11.1.B7 | bromide peroxidase (heme-containing) |
endosome |
recycling |
GO:0005768 AmiGO QuickGO |
765047 |
1.6.1.2 | NAD(P)+ transhydrogenase (Re/Si-specific) |
endosome |
- |
GO:0005768 AmiGO QuickGO |
711879 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
endosome |
- |
GO:0005768 AmiGO QuickGO |
724778 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
endosome |
NOX1, Nox1 stimulation in endosomes is dependent on ClC-3, where this ion exchanger is required to balance the electrogenic activity of the enzyme |
GO:0005768 AmiGO QuickGO |
724778 |
2.1.1.233 | [phosphatase 2A protein]-leucine-carboxy methyltransferase |
endosome |
the enzyme is underrepresented in the nucleus and mainly localized to the cytoplasm, Golgi region and late endosomes |
GO:0005768 AmiGO QuickGO |
714919 |
2.1.1.336 | norbelladine O-methyltransferase |
endosome |
the enzyme is mainly localized in cytoplasm and endosome |
GO:0005768 AmiGO QuickGO |
756993 |
2.1.1.354 | [histone H3]-lysine4 N-trimethyltransferase |
endosome |
Dpy-30 functions in the endosome to trans-Golgi network transport of cation-independent mannose 6-phosphate receptor |
GO:0005768 AmiGO QuickGO |
704780 |
2.1.2.3 | phosphoribosylaminoimidazolecarboxamide formyltransferase |
endosome |
the enzyme later accumulates in the Golgi/endosome network |
GO:0005768 AmiGO QuickGO |
736802 |
2.3.1.225 | protein S-acyltransferase |
endosome |
- |
GO:0005768 AmiGO QuickGO |
720754 |
2.3.1.78 | heparan-alpha-glucosaminide N-acetyltransferase |
endosome |
HGSNAT coimmunoprecipitates with antibodies to ALIX, which is associated with the endosomal sorting complexes required for transport proteins |
GO:0005768 AmiGO QuickGO |
756105 |
2.3.2.26 | HECT-type E3 ubiquitin transferase |
endosome |
isoform Itch co-localizes with markers of the endosomal system in a C2 domain-dependent manner and upon EGF stimulation, substrate endophilin A1 translocates to an EGF-positive endosomal compartment where it colocalizes with itch |
GO:0005768 AmiGO QuickGO |
734144 |
2.3.2.27 | RING-type E3 ubiquitin transferase |
endosome |
- |
GO:0005768 AmiGO QuickGO |
734920 |
2.5.1.58 | protein farnesyltransferase |
endosome |
- |
GO:0005768 AmiGO QuickGO |
737611 |
2.7.1.107 | diacylglycerol kinase (ATP) |
endosome |
- |
GO:0005768 AmiGO QuickGO |
672450, 761306 |
2.7.1.107 | diacylglycerol kinase (ATP) |
endosome |
DGKeta1 and DGKeta2 are rapidly translocated from the cytoplasm to endosomes in response to stress stimuli. DGKeta1 is rapidly relocated back to the cytoplasm upon removal of stress stimuli. DGKeta2 exhibits sustained endosomal association. Oligomerization of DGKeta2 mediated by its SAM domain is largely responsible for its sustained endosomal localization |
GO:0005768 AmiGO QuickGO |
640389 |
2.7.1.137 | phosphatidylinositol 3-kinase |
endosome |
- |
GO:0005768 AmiGO QuickGO |
709868, 760521, 760661, 762179 |
2.7.1.137 | phosphatidylinositol 3-kinase |
endosome |
late |
GO:0005768 AmiGO QuickGO |
761826 |
2.7.1.150 | 1-phosphatidylinositol-3-phosphate 5-kinase |
endosome |
localizes mainly to early endosomes. PIKfyve is distributed in microdomains |
GO:0005768 AmiGO QuickGO |
673833 |
2.7.1.150 | 1-phosphatidylinositol-3-phosphate 5-kinase |
endosome |
PIKfyve is predominantly associated with the early endosome, from where it regulates retrograde membrane trafficking to the trans-Golgi-network |
GO:0005768 AmiGO QuickGO |
675013 |
2.7.1.150 | 1-phosphatidylinositol-3-phosphate 5-kinase |
endosome |
the enzyme predominantly localizes on the Sorting Nexin1 (SNX1)-residing late endosomes, the SNX1-positive endosomes |
GO:0005768 AmiGO QuickGO |
739357 |
2.7.1.33 | pantothenate kinase |
endosome |
isozyme 1beta |
GO:0005768 AmiGO QuickGO |
759477 |
2.7.1.67 | 1-phosphatidylinositol 4-kinase |
endosome |
- |
GO:0005768 AmiGO QuickGO |
-, 674999, 722121, 723136, 723790, 759289, 759590 |
2.7.1.67 | 1-phosphatidylinositol 4-kinase |
endosome |
dynamic tubular, PI4KII |
GO:0005768 AmiGO QuickGO |
722098 |
2.7.1.67 | 1-phosphatidylinositol 4-kinase |
endosome |
endosome |
GO:0005768 AmiGO QuickGO |
641814 |
2.7.1.67 | 1-phosphatidylinositol 4-kinase |
endosome |
isoozyme PI4KIIalpha |
GO:0005768 AmiGO QuickGO |
723138 |
2.7.1.68 | 1-phosphatidylinositol-4-phosphate 5-kinase |
endosome |
- |
GO:0005768 AmiGO QuickGO |
738090 |
2.7.1.68 | 1-phosphatidylinositol-4-phosphate 5-kinase |
endosome |
localizes mainly to early endosomes. PIKfyve is distributed in microdomains |
GO:0005768 AmiGO QuickGO |
673833 |
2.7.1.91 | sphingosine kinase |
endosome |
enzymes cycles between trans-Golgi network and late endosomes, facing the cytosol |
GO:0005768 AmiGO QuickGO |
492175 |
2.7.10.1 | receptor protein-tyrosine kinase |
endosome |
PDGFR-beta activates various signaling pathways within endosomes including PI-3K/Akt in human hepatocellular carcinoma cell line |
GO:0005768 AmiGO QuickGO |
693727 |
2.7.10.2 | non-specific protein-tyrosine kinase |
endosome |
- |
GO:0005768 AmiGO QuickGO |
695228 |
2.7.11.1 | non-specific serine/threonine protein kinase |
endosome |
at late endosome and vacuole interface |
GO:0005768 AmiGO QuickGO |
-, 723177 |
2.7.11.1 | non-specific serine/threonine protein kinase |
endosome |
isozyme PKNalpha |
GO:0005768 AmiGO QuickGO |
662053 |
2.7.11.13 | protein kinase C |
endosome |
activated PKCbetaII and PKCbetaI are translocated from cytosol, juxtanuclear location, isozyme-specific translocation of PKCbetaII and not PKCbetaI to a juxtanuclear subset of recycling endosomes, involvement of phospholipase D |
GO:0005768 AmiGO QuickGO |
662235 |
2.7.4.21 | inositol-hexakisphosphate 5-kinase |
endosome |
- |
GO:0005768 AmiGO QuickGO |
-, 737654 |
2.7.7.1 | nicotinamide-nucleotide adenylyltransferase |
endosome |
in HeLa cells, in addition to Golgi, isoform Nmnat2 localizes to Rab7-containing late endosomes |
GO:0005768 AmiGO QuickGO |
722694 |
2.7.8.8 | CDP-diacylglycerol-serine O-phosphatidyltransferase |
endosome |
early endosomes |
GO:0005768 AmiGO QuickGO |
739446 |
3.1.1.53 | sialate O-acetylesterase |
endosome |
- |
GO:0005768 AmiGO QuickGO |
94414 |
3.1.3.36 | phosphoinositide 5-phosphatase |
endosome |
- |
GO:0005768 AmiGO QuickGO |
751176 |
3.1.3.36 | phosphoinositide 5-phosphatase |
endosome |
dOCRL is associated with endosomes |
GO:0005768 AmiGO QuickGO |
714782 |
3.1.3.4 | phosphatidate phosphatase |
endosome |
early stage, wild-type and mutant |
GO:0005768 AmiGO QuickGO |
680744 |
3.1.3.48 | protein-tyrosine-phosphatase |
endosome |
receptor-type isoforms PTPBR7 and PTP-SL |
GO:0005768 AmiGO QuickGO |
691726 |
3.1.3.64 | phosphatidylinositol-3-phosphatase |
endosome |
- |
GO:0005768 AmiGO QuickGO |
716970 |
3.1.3.64 | phosphatidylinositol-3-phosphatase |
endosome |
late endosome |
GO:0005768 AmiGO QuickGO |
750697 |
3.1.3.64 | phosphatidylinositol-3-phosphatase |
endosome |
membranes of late endosome, MTMR2-MTMR13 complex |
GO:0005768 AmiGO QuickGO |
665651 |
3.1.3.64 | phosphatidylinositol-3-phosphatase |
endosome |
MTM1 is present on ruffles at the plasma membrane, on early endosomes and partially on late endosomes |
GO:0005768 AmiGO QuickGO |
715016 |
3.1.3.64 | phosphatidylinositol-3-phosphatase |
endosome |
MTM1 localizes to both early and late endosomes and associates with the hVPS15/hVPS34 complex. Both Rab7 and MTM1 bind to hVPS15, the hVPS34 adapter molecule that regulates hVPS34 activity through its interactions with Rab5 and Rab7. The WD40 domain of hVPS15 mediates binding to Rab5, Rab7 and MTM1. Consequently, binding of the hVPS15/hVPS34 complex to the Rab GTPases and MTM1 is mutually exclusive |
GO:0005768 AmiGO QuickGO |
682936 |
3.1.3.64 | phosphatidylinositol-3-phosphatase |
endosome |
predominantly |
GO:0005768 AmiGO QuickGO |
715992 |
3.1.3.64 | phosphatidylinositol-3-phosphatase |
endosome |
treatment with multiple MAPK inhibitors results in a MTMR2 localization shift from Rab5-positive endosomes to the more proximal APPL1-positive endosomes |
GO:0005768 AmiGO QuickGO |
732221 |
3.1.3.66 | phosphatidylinositol-3,4-bisphosphate 4-phosphatase |
endosome |
early and recycling endosome |
GO:0005768 AmiGO QuickGO |
666295 |
3.1.3.95 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase |
endosome |
- |
GO:0005768 AmiGO QuickGO |
750697 |
3.1.3.B4 | phosphatidylinositol-4-phosphate phosphatase |
endosome |
- |
GO:0005768 AmiGO QuickGO |
751173, 752310 |
3.1.4.12 | sphingomyelin phosphodiesterase |
endosome |
- |
GO:0005768 AmiGO QuickGO |
730294 |
3.1.4.12 | sphingomyelin phosphodiesterase |
endosome |
localizes to the lumen of endosomes |
GO:0005768 AmiGO QuickGO |
691696 |
3.1.4.4 | phospholipase D |
endosome |
- |
GO:0005768 AmiGO QuickGO |
707544 |
3.1.4.4 | phospholipase D |
endosome |
isozyme PLD1 |
GO:0005768 AmiGO QuickGO |
730316 |
3.1.4.4 | phospholipase D |
endosome |
late endosome, PLD1 |
GO:0005768 AmiGO QuickGO |
649327 |
3.1.6.1 | arylsulfatase (type I) |
endosome |
- |
GO:0005768 AmiGO QuickGO |
707966 |
3.2.1.14 | chitinase |
endosome |
late |
GO:0005768 AmiGO QuickGO |
664449 |
3.2.1.166 | heparanase |
endosome |
late |
GO:0005768 AmiGO QuickGO |
754873 |
3.2.1.166 | heparanase |
endosome |
late endosomes |
GO:0005768 AmiGO QuickGO |
753404 |
3.2.1.18 | exo-alpha-sialidase |
endosome |
- |
GO:0005768 AmiGO QuickGO |
656030, 730792 |
3.4.11.3 | cystinyl aminopeptidase |
endosome |
insulin-stimulated translocation of IRAP remains intact despite substantial knock-down of glucose transporter GLUT4. By contrast, insulin-stimulated GLUT4 translocation is impaired upon IRAP knock-down. Tankyrase knock-down alters the basal partitioning of GLUT4 and IRAP within endosomal compartments |
GO:0005768 AmiGO QuickGO |
683133 |
3.4.14.1 | dipeptidyl-peptidase I |
endosome |
in B-lymphoblastoid cells cathepsin is distrubuted between late endosomes and lysosomes |
GO:0005768 AmiGO QuickGO |
665954 |
3.4.17.22 | metallocarboxypeptidase D |
endosome |
DCPD, glycine decarboxylase and duck Hepatitis B virus large enveloppe protein are colocalized in the endosomal fraction of duck hepatocytes |
GO:0005768 AmiGO QuickGO |
709747 |
3.4.19.12 | ubiquitinyl hydrolase 1 |
endosome |
- |
GO:0005768 AmiGO QuickGO |
680865 |
3.4.19.12 | ubiquitinyl hydrolase 1 |
endosome |
associated to |
GO:0005768 AmiGO QuickGO |
665794 |
3.4.19.12 | ubiquitinyl hydrolase 1 |
endosome |
cytosolic side |
GO:0005768 AmiGO QuickGO |
646105 |
3.4.19.12 | ubiquitinyl hydrolase 1 |
endosome |
the C-terminal proline-rich domain of Bro1 participates in recruitment of the Doa4 ubiquitin hydrolase to the endosome |
GO:0005768 AmiGO QuickGO |
679593 |
3.4.19.12 | ubiquitinyl hydrolase 1 |
endosome |
the important function of Doa4 in Gap1 endocytosis operates at the late endosome stage |
GO:0005768 AmiGO QuickGO |
682937 |
3.4.21.105 | rhomboid protease |
endosome |
membranes of the late endosome compartment |
GO:0005768 AmiGO QuickGO |
683408 |
3.4.21.109 | matriptase |
endosome |
membrane-bound form |
GO:0005768 AmiGO QuickGO |
732419 |
3.4.21.75 | Furin |
endosome |
- |
GO:0005768 AmiGO QuickGO |
709747, 732149, 753199 |
3.4.21.75 | Furin |
endosome |
basolateral |
GO:0005768 AmiGO QuickGO |
668204 |
3.4.21.75 | Furin |
endosome |
furin localizes to endosomes when Mint3 expression is knocked down |
GO:0005768 AmiGO QuickGO |
699103 |
3.4.21.75 | Furin |
endosome |
hypoxia triggers relocalization of furin from the trans-Golgi network to endosomomal compartments and the cell surface in cancer cells |
GO:0005768 AmiGO QuickGO |
717903 |
3.4.21.79 | granzyme B |
endosome |
both perforin and GzmB are endocytosed into giant endosomal antigen-1 endosomes that form after perforin treatment |
GO:0005768 AmiGO QuickGO |
707853 |
3.4.21.B27 | proprotein convertase 7 |
endosome |
- |
GO:0005768 AmiGO QuickGO |
731888 |
3.4.21.B27 | proprotein convertase 7 |
endosome |
only overexpressed PC7 activity reaches the cell surface, endosomes, and the trans-Golgi network |
GO:0005768 AmiGO QuickGO |
753199 |
3.4.22.1 | cathepsin B |
endosome |
cathepsin B is synthesised as a pre-pro-enzyme and the primary pathways for its normal trafficking to the lysosome utilise mannose-6-phosphate receptors. Inactive pro-cathepsin-B is processed to active single and double chain forms of cathepsin-B in the late endosomes and lysosomes, respectively |
GO:0005768 AmiGO QuickGO |
698146 |
3.4.22.15 | cathepsin L |
endosome |
- |
GO:0005768 AmiGO QuickGO |
713584 |
3.4.22.27 | cathepsin S |
endosome |
- |
GO:0005768 AmiGO QuickGO |
668479, 668898, 698859 |
3.4.22.27 | cathepsin S |
endosome |
co-localized with CX3CL1 |
GO:0005768 AmiGO QuickGO |
733448 |
3.4.22.34 | Legumain |
endosome |
- |
GO:0005768 AmiGO QuickGO |
650471, 650474, 701007, 731376 |
3.4.22.40 | bleomycin hydrolase |
endosome |
- |
GO:0005768 AmiGO QuickGO |
717821 |
3.4.22.B65 | cathepsin P |
endosome |
cathepsin P co-localizes with cathepsin B and may function in an endosomal-lysosomal compartment |
GO:0005768 AmiGO QuickGO |
700693 |
3.4.23.34 | cathepsin E |
endosome |
- |
GO:0005768 AmiGO QuickGO |
678531, 679774 |
3.4.23.34 | cathepsin E |
endosome |
CatE is normally most acitve at acidic pH, which corresponds to the active endosomal form |
GO:0005768 AmiGO QuickGO |
677973 |
3.4.23.34 | cathepsin E |
endosome |
cathepsin E is localized in endosomal structures of antigen-presenting cells |
GO:0005768 AmiGO QuickGO |
681209 |
3.4.23.34 | cathepsin E |
endosome |
in antigen-presenting cells such as microglia, dendritic cells and macrophagess CatE is mainly present in the endosomal compartments |
GO:0005768 AmiGO QuickGO |
677990 |
3.4.23.46 | memapsin 2 |
endosome |
- |
GO:0005768 AmiGO QuickGO |
638909, 711429, 712811, 753969 |
3.4.23.46 | memapsin 2 |
endosome |
BACE1, minor presence |
GO:0005768 AmiGO QuickGO |
638914 |
3.4.23.46 | memapsin 2 |
endosome |
cycling of BACE1 between cell surface and the endosomal system, activation during cellular trafficking |
GO:0005768 AmiGO QuickGO |
683141 |
3.4.23.46 | memapsin 2 |
endosome |
cycling of BACE1 between the cell surface and the endosomal system, activation of BACE1 interconvertible during cellular trafficking |
GO:0005768 AmiGO QuickGO |
683872 |
3.4.23.5 | cathepsin D |
endosome |
- |
GO:0005768 AmiGO QuickGO |
35013, 697479, 698022, 711326 |
3.4.24.56 | insulysin |
endosome |
- |
GO:0005768 AmiGO QuickGO |
710682 |
3.4.24.56 | insulysin |
endosome |
binding to phosphatdidylinositol phosphates facilitates its localization to endosomes |
GO:0005768 AmiGO QuickGO |
755263 |
3.4.24.71 | endothelin-converting enzyme 1 |
endosome |
- |
GO:0005768 AmiGO QuickGO |
697033, 709039, 734021, 734268, 734370 |
3.4.24.71 | endothelin-converting enzyme 1 |
endosome |
early |
GO:0005768 AmiGO QuickGO |
683696 |
3.4.24.71 | endothelin-converting enzyme 1 |
endosome |
early endosomes from sequestration of recombinant somatostatin receptor subtype 2A, sst2A, in HEK-293 cells after induction by somatostatin-14 or octreotide, co-localization od ECE-1 and sst2A, overview |
GO:0005768 AmiGO QuickGO |
683416 |
3.4.24.81 | ADAM10 endopeptidase |
endosome |
- |
GO:0005768 AmiGO QuickGO |
696395 |