EC Number |
Localization |
GeneOntology No. |
Reference |
---|
4.4.1.17 | integral to membrane |
- |
- |
94055, 94058 |
4.4.1.17 | mitochondrial inner membrane |
- |
GO:0005743 AmiGO QuickGO |
94056, 94057, 94058 |
4.4.1.17 | mitochondrial inner membrane |
integral membrane protein, facing cytoplasmic surface |
GO:0005743 AmiGO QuickGO |
94055 |
4.4.1.17 | mitochondrial inner membrane |
separation of mitochondrial inner and outer membrane on a sucrose gradient |
GO:0005743 AmiGO QuickGO |
665678 |
4.4.1.17 | mitochondrial intermembrane space |
enzyme is transported into the intermembrane space via a direct sorting pathway, that can occur in absence of external energy sources |
GO:0005758 AmiGO QuickGO |
651850 |
4.4.1.17 | mitochondrial intermembrane space |
novel, non-conservative import pathway: the enzyme precursor is translocated into mitochondria using the MOM19-GIP receptor complex in the outer membrane, independent of ATP-hydrolysis and electrochemical potential as external energy source |
GO:0005758 AmiGO QuickGO |
94058 |
4.4.1.17 | mitochondrial membrane |
membrane-bound |
GO:0031966 AmiGO QuickGO |
730827 |
4.4.1.17 | mitochondrion |
- |
GO:0005739 AmiGO QuickGO |
651895, 677440, 715034, 729264, 729740, 730058, 730322, 94056 |
4.4.1.17 | mitochondrion |
detected by Western analysis |
GO:0005739 AmiGO QuickGO |
653258 |
4.4.1.17 | mitochondrion |
during apoptotic stimuli, enzyme translocates to outside the mitochondria, and binds to and suppresses the X-linked inhibitor of apoptosis protein XIAP, leading to activation of caspase-3. The N-terminus of the neuronal glutamate transporter excitatory amino-acid carrier 1 EAAC1 can bind to enzyme which interferes with the enzyme-XIAP association |
GO:0005739 AmiGO QuickGO |
679489 |