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EC Number
Localization
Commentary
GeneOntology No.
Reference
integral membrane protein, facing cytoplasmic surface
separation of mitochondrial inner and outer membrane on a sucrose gradient
enzyme is transported into the intermembrane space via a direct sorting pathway, that can occur in absence of external energy sources
novel, non-conservative import pathway: the enzyme precursor is translocated into mitochondria using the MOM19-GIP receptor complex in the outer membrane, independent of ATP-hydrolysis and electrochemical potential as external energy source
detected by Western analysis
during apoptotic stimuli, enzyme translocates to outside the mitochondria, and binds to and suppresses the X-linked inhibitor of apoptosis protein XIAP, leading to activation of caspase-3. The N-terminus of the neuronal glutamate transporter excitatory amino-acid carrier 1 EAAC1 can bind to enzyme which interferes with the enzyme-XIAP association
Results 1 - 10 of 14 > >>