EC Number   |
Localization |
GeneOntology No. |
Reference  |
|---|
   3.4.22.49 | more |
Separase is present in the cell during the entire cell cycle, but excluded from the nucleus until the metaphase-anaphase transition |
- |
700280 |
| 3.4.22.49 | more |
budding yeast Esp1 is localized to the centrosomes and spindle before anaphase |
- |
718194 |
| 3.4.22.49 | more |
human separase is associated with centrosomes but not with spindle before anaphase, featuring predominantly cytoplasmic localization in non-dividing cells |
- |
718194 |
| 3.4.22.49 | more |
in fission yeast Cut1 features similar localization in the beginning of anaphase onset persisting on the spindle until mid-anaphase |
- |
718194 |
| 3.4.22.49 | cytoplasm |
separase is abundantly expressed within the cytoplasm of a broad range of human tumor cell lines, including MDA-MB-231 breast carcinoma cells |
GO:0005737 AmiGO QuickGO |
718433 |
| 3.4.22.49 | membrane |
- |
GO:0016020 AmiGO QuickGO |
718433 |
| 3.4.22.49 | centrosome |
- |
GO:0005813 AmiGO QuickGO |
731689, 732669, 732703 |
| 3.4.22.49 | chromosome |
the spatial localization of separase varies with the progression of the cell cycle. In interphase cells, separase is localized in the cytoplasm, but during mitosis it accumulates in the nucleus and associates with chromosomes |
GO:0005694 AmiGO QuickGO |
752903 |
| 3.4.22.49 | cytoplasm |
the spatial localization of separase varies with the progression of the cell cycle. In interphase cells, separase is localized in the cytoplasm, but during mitosis it accumulates in the nucleus and associates with chromosomes |
GO:0005737 AmiGO QuickGO |
752903 |
| 3.4.22.49 | nucleus |
the spatial localization of separase varies with the progression of the cell cycle. In interphase cells, separase is localized in the cytoplasm, but during mitosis it accumulates in the nucleus and associates with chromosomes |
GO:0005634 AmiGO QuickGO |
752903 |
