EC Number |
Localization |
GeneOntology No. |
Reference |
---|
2.3.1.135 | endoplasmic reticulum |
before initiation of retinyl ester biosynthesis, LRAT distributes throughout the endoplasmic reticulum, and Crpb1 localizes with mitochondria associated membranes, surrounded by LRAT. Upon initiating retinyl ester biosynthesis in cells, Crpb1 remains with MAM, and both Crbp1 and MAM re-localize with LRAT. LRAT formed rings around the growing lipid droplets |
GO:0005783 AmiGO QuickGO |
718992 |
2.3.1.135 | endoplasmic reticulum membrane |
LRAT is localized to the membrane of the LRAT is localized to the membrane of the endoplasmic reticulum. Single membrane-spanning protein with an N-terminal domain that faces the cytoplasm |
GO:0005789 AmiGO QuickGO |
674832 |
2.3.1.135 | endoplasmic reticulum membrane |
LRATis a single membrane-spanning protein with an N-terminal domain that faces the cytoplasm, C-terminal luminal orientation, membrane topology, overview |
GO:0005789 AmiGO QuickGO |
674832 |
2.3.1.135 | lipid droplet |
upon initiating retinyl ester biosynthesis in cells, Crpb1 remains with MAM, and both Crbp1 and MAM re-localize with LRAT. LRAT formed rings around the growing lipid droplets. LRAT-containing rings colocalize with the lipid-droplet surface proteins, desnutrin/adipose triglyceride lipase and perilipin 2. Colocalization with lipid droplets requires the 38 N-terminal amino acid residues of LRAT, and specifically K36 and R38. Formation of rings around the growing lipid droplets does not require functional microtubules |
GO:0005811 AmiGO QuickGO |
718992 |
2.3.1.135 | membrane |
- |
GO:0016020 AmiGO QuickGO |
658661, 658662, 672075 |
2.3.1.135 | membrane |
boound |
GO:0016020 AmiGO QuickGO |
719417 |
2.3.1.135 | membrane |
bound, membrane topology model of LRAT using I-TASSER, membrane interaction probes of LRAT and truncated LRAT with phospholipid monolayers, circular dichroism, overview |
GO:0016020 AmiGO QuickGO |
720353 |
2.3.1.135 | membrane |
integral |
GO:0016020 AmiGO QuickGO |
658001 |
2.3.1.135 | membrane |
membrane-associated protein |
GO:0016020 AmiGO QuickGO |
685367 |
2.3.1.135 | microsome |
- |
- |
487491, 638608, 638613, 638625, 658662, 674487, 758200 |