EC Number |
Localization |
GeneOntology No. |
Reference |
---|
3.4.22.49 | nucleus |
possibly localized in the nucleus, in the mitotic stage Cut1 is mobilized to the spindle poles and the spindle microtubules |
GO:0005634 AmiGO QuickGO |
638856 |
3.4.22.49 | cytoplasm |
prodominant localisation |
GO:0005737 AmiGO QuickGO |
700280 |
3.4.22.49 | more |
separase binds terminin proteins and HP1, and that it is enriched at telomeres |
- |
754836 |
3.4.22.49 | cytoplasm |
separase is abundantly expressed within the cytoplasm of a broad range of human tumor cell lines, including MDA-MB-231 breast carcinoma cells |
GO:0005737 AmiGO QuickGO |
718433 |
3.4.22.49 | more |
Separase is present in the cell during the entire cell cycle, but excluded from the nucleus until the metaphase-anaphase transition |
- |
700280 |
3.4.22.49 | more |
separase localizes to cortically located filamentous structures in prometaphase I upon oocyte maturation. After fertilization, separase disappears from these structures and appears on cortical granules by anaphase I |
- |
679433 |
3.4.22.49 | chromosome |
the spatial localization of separase varies with the progression of the cell cycle. In interphase cells, separase is localized in the cytoplasm, but during mitosis it accumulates in the nucleus and associates with chromosomes |
GO:0005694 AmiGO QuickGO |
752903 |
3.4.22.49 | cytoplasm |
the spatial localization of separase varies with the progression of the cell cycle. In interphase cells, separase is localized in the cytoplasm, but during mitosis it accumulates in the nucleus and associates with chromosomes |
GO:0005737 AmiGO QuickGO |
752903 |
3.4.22.49 | nucleus |
the spatial localization of separase varies with the progression of the cell cycle. In interphase cells, separase is localized in the cytoplasm, but during mitosis it accumulates in the nucleus and associates with chromosomes |
GO:0005634 AmiGO QuickGO |
752903 |
3.4.22.49 | nucleus |
tumor cells significantly more abundant, immunofluorescence microscopy |
GO:0005634 AmiGO QuickGO |
697382 |