EC Number |
Inhibitors |
Structure |
---|
5.6.1.7 | 4-Chloro-7-nitrobenzo-2-oxa-1,3-diazole |
0.1 mM, 31% inhibition |
|
5.6.1.7 | ADP |
more than 80% inhibition at 10fold excess of ADP |
|
5.6.1.7 | ADP |
strongly competitively inhibits PfCPN ATPase activity. Addition of an equimolar amount of ADP results in a 48% inhibition of ATPase activity. When ADP concentration is four times that of ATP, the PfCPN ATPase activity decreases to 10% of that without ADP. Inhibition of PfCPN ATPase decreases its chaperonin activity in protecting lysozyme from heat-induced inactivation |
|
5.6.1.7 | AMP |
when AMP concentration is 8 times that of ATP, AMP inhibits the ATPase activity to 48% |
|
5.6.1.7 | AMP-PNP |
2 mM, 90% inhibition |
|
5.6.1.7 | arsenic |
arsenic inhibits TRiC function, required for folding of actin, tubulin, and other proteins post-synthesis |
|
5.6.1.7 | ATP |
inhibitis RNA binding and processing by the enzyme |
|
5.6.1.7 | ATP |
addititon of ATP impaired the ability of wild-type chaperonin to protect citrate synthase from thermal aggregation |
|
5.6.1.7 | ATP |
high ATP concentrations causes release of bound substrate |
|
5.6.1.7 | ATP-gammaS |
complete inhibition of ATPase activity |
|