EC Number   |
Inhibitors |
Structure |
|---|
   5.6.1.4 | 5'-adenylylimidodiphosphate |
AMP-PNP above 2.5 mM |
   |
| 5.6.1.4 | 5'-adenylylimidodiphosphate |
- |
|
| 5.6.1.4 | Acrylamide |
kinesin inhibition is observed at acrylamide concentrations as low as 0.1 mM |
|
| 5.6.1.4 | BTB-1 |
BTB-1 inhibits both of the microtubule-based Kif18A activities. Allosteric BTB-1-binding site near loop5, where it blocks the ATP-dependent conformational changes |
|
| 5.6.1.4 | glycidamide |
kinesin inhibition is observed at glycidamide concentrations as low as 0.1 mM |
|
| 5.6.1.4 | importin alpha/beta |
binding of importin alpha/beta to XCTK2 inhibits its association with microtubules and blocks its ability to cross-link microtubules |
|
| 5.6.1.4 | Kar3 |
Ncd and Kar3, both minus-end motors, severely inhibit the binding of one another to microtubules |
|
| 5.6.1.4 | monastrol |
application results in kinetochore fibers oriented away fom, and not directly connected to, centrosomes and incorporated into the spindle by the sliding of their distal ends toward centrosomes |
|
| 5.6.1.4 | more |
in contrast to cytoplasmic dynein, ncd polypeptide is not cleaved by UV-vanadate treatment, and its ATPase and motility are unaffected by vanadate (up to 0.1 mM) |
|
| 5.6.1.4 | more |
Ran regulates the association of kinesin-14 with importin alpha/beta to prevent aberrant cross-linking and bundling of microtubules by sequestering kinesin-14 in the nucleus during interphase |
|
