EC Number   |
Inhibitors |
Structure |
|---|
   5.6.1.2 | 2-(7-chloro-4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)-3-(2,4-dichlorophenyl)-3-oxopropanenitrile |
ciliobrevin D, at 0.025 mM about 50% inhibition |
   |
| 5.6.1.2 | 2-(7-chloro-4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)-3-(2,4-dichlorophenyl)-3-oxopropanenitrile |
ciliobrevin D |
|
| 5.6.1.2 | 3-(2,4-dichlorophenyl)-3-oxo-2-(4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)propanenitrile |
ciliobrevin A, at 0.1 mM more than 50% inhibition |
|
| 5.6.1.2 | 3-(2,4-dichlorophenyl)-3-oxo-2-(4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)propanenitrile |
ciliobrevin A |
|
| 5.6.1.2 | Adenylyl imidodiphosphate |
competitive inhibition |
|
| 5.6.1.2 | AlCl3 |
1 mM, complete inhibition |
|
| 5.6.1.2 | antibody 70.1 |
antibody raised against the intermediate chain of dynein, exerts a functional inhibitory effect upon dynein function by preventing its association with the accessory complex dynactin. Treatment with 70.1 prevents formation of the prominent endoplasmic reticulum ring characteristic of metaphase I oocytes |
|
| 5.6.1.2 | antibody 74.1 |
monoclonal antibody directed against the dynein intermediate chain. Antibody prevents binding of the dynein intermediate chain to the p150Glued subunit of dynactin and disrupts the dynein-dynactin complex without having an effect on the dynactin structure. Inhibition induces rapid loss of radial microtubule organization, while the levels of key centrososmal proteins or the rates of microtubule nucleation do not change significantly |
|
| 5.6.1.2 | Cd2+ |
the enzyme is maximally inhibited by 25 nM free Cd2+ in the assay medium, with a K(50%) inhibition of 11.3 nM Cd2+. The decreased activity of the sperm ATPases might have a critical importance in the biochemical mechanisms underlying the decreased sperm motility of individuals exposed to Cd2+ |
|
| 5.6.1.2 | ciliobrevin A |
decreases flagellar beat frequency of swimming parasites in a concentration dependent manner. Beat frequency of live and reactivated Leishmania donovani decreases by approximately 89% and 41% respectively in the presence of 0.25 mM ciliobrevin A. This inhibition is lost when ciliobrevin A is removed, suggesting its effects are reversible |
|
