EC Number |
Inhibitors |
Structure |
---|
5.4.99.4 | (Z)-glutaconate |
mechanism-based inactivation. Inhibitor induces homolysis of the Co-C bond of coenzyme B12 to afford cob(II)alamin and the 5'-deoxyadenosyl radical. The 5'-deoxyadenosyl radical adds to the double bond of (Z)-glutaconate to afford a radical adduct and subsequent formation of aquocobalamin |
|
5.4.99.4 | 1-Methyl-1,2-cis-cyclopropanedicarboxylate |
noncompetitive, slight inhibitor |
|
5.4.99.4 | 1-Methyl-1,2-cis-cyclopropanedicarboxylate |
- |
|
5.4.99.4 | 1-Methyl-1,2-trans-cyclopropanedicarboxylate |
competitive |
|
5.4.99.4 | 1-Methyl-1,2-trans-cyclopropanedicarboxylate |
- |
|
5.4.99.4 | 1-methylcyclopropane-(1R,2R)-dicarboxylate |
weak noncompetitive |
|
5.4.99.4 | buta-1,3-diene-2,3-dicarboxylate |
mechanism-based inactivation. Inhibitor induces homolysis of the Co-C bond of coenzyme B12 to afford cob(II)alamin and the 5'-deoxyadenosyl radical. The 5'-deoxyadenosyl radical adds to a double bond of buta-1,3-diene-2,3-dicarboxylate to afford a relatively stable radical adduct in the active site of the enzyme |
|
5.4.99.4 | citrate |
slight |
|
5.4.99.4 | glutaconate |
noncompetitive |
|
5.4.99.4 | glutaconate |
- |
|