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EC Number
Inhibitors
Commentary
Structure
5.1.1.11
1-Phenylethylamine
-
5.1.1.11
5,5'-dithiobis(2-nitrobenzoate)
presence of ATP, MgCl2, and dithiothreitol prevent rapid sulfhydryl modification. With the enzyme of a gramicidin S non-producing and phenylalanine racemization-lacking mutant the substrate protection against rapid sulfhydryl modification is not detected
5.1.1.11
cyanide
-
5.1.1.11
cystamine
Mg2+ alone or in combination with the substrates ATP and Phe causes significant protection. Cystamine-inactivated enzyme can be reactivated by treatment with dithioerythritol or other sulfhydryl compounds. 0.5 M cystamine causes 90%, 40% and 30% loss in activity if preincubated at 37°C, 20°C, or 0°C for 20 min
5.1.1.11
cysteamine
-
5.1.1.11
DL-cystine
-
5.1.1.11
Hydrocinnamic acid
-
5.1.1.11
hydroxylamine
-
5.1.1.11
isoniazid
-
5.1.1.11
L-1-Bromo-3-amino-4-phenyl-butan-2-one
irreversible
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