EC Number   |
Inhibitors |
Structure |
|---|
   4.1.3.42 | 2-Ketoglutarate |
- |
   |
| 4.1.3.42 | 4-(Oxyacetyl)phenoxyacetic acic |
inactivates arginine residues, 90% inactivation at 10 mM |
|
| 4.1.3.42 | 4-mercuribenzenesulfonic acid |
1 mM, 56% inhibition |
|
| 4.1.3.42 | acetaldehyde |
Ki: 11 mM |
|
| 4.1.3.42 | Bromopyruvate |
85% inhibition at 1 mM, pyruvate or 2-keto-4-hydroxyglutarate protect; substrate analog. Treatment results in a time- and concentration-dependent loss of enzymatic activity. The substrates pyruvate and 2-keto-4-hydroxyglutarate provide more than 90% protection against inactivation by bromopyruvate, no protective effect is seen with glycolaldehyde. 1.1 mol of bromopyruvate is incorporated per enzyme subunit by esterification of residue Glu45 |
|
| 4.1.3.42 | chloride |
41% inhibition at 40 mM |
|
| 4.1.3.42 | citrate |
Ki: 7.5 mM |
|
| 4.1.3.42 | CN- |
irreversible, in presence of 4-hydroxy-2-oxoglutarate; irreversible loss of activity in presence of glyoxylate, but not in presence of pyruvate |
|
| 4.1.3.42 | glyoxylate |
bovine enzyme inhibited at lower concentrations than E. coli enzyme |
|
| 4.1.3.42 | glyoxylate |
substrate inhibition. Glyoxylate competes for, and inhibits aldolase activity by reacting with, the one active-site lysine residue/subunit |
|
