EC Number   |
Inhibitors |
Structure |
|---|
    4.1.2.4 | acetaldehyde |
the wild type enzyme is highly resistant to high concentrations of acetaldehyde, whereas the recombinant DERA is almost completely inactivated after a 2 h exposure at 25°C |
   |
| 4.1.2.4 | acetaldehyde |
the wild type enzyme is highly resistant to high concentrations of acetaldehyde |
|
| 4.1.2.4 | acetaldehyde |
the activity of wild-type enzyme sharply dropps by 43 % under 200 mM D-glyceraldehyde and acetaldehyde, which limits its large-scale synthetic applications |
|
| 4.1.2.4 | acetaldehyde |
- |
|
| 4.1.2.4 | acrolein |
irreversible, no inactivation after prolonged incubation with glycidol phosphate and glycidaldehyde |
|
| 4.1.2.4 | Chloral hydrate |
- |
|
| 4.1.2.4 | Chloroacetaldehyde |
the enzyme is rapidly and irreversibly inactivated and loses 84.9% of its enzymatic activity in the presence of 200 mM chloroacetaldehyde |
|
| 4.1.2.4 | crotonaldehyde |
the enzyme produces crotonaldehyde as side reaction from acetaldehyde which is then an irreversible inhibitor forming a covalent Michael-adduct within the active site in particular with cysteine 47 |
|
| 4.1.2.4 | D-glyceraldehyde |
the activity of wild-type enzyme sharply dropps by 43 % under 200 mM D-glyceraldehyde and acetaldehyde, which limits its large-scale synthetic applications |
|
| 4.1.2.4 | hydroxylamine |
- |
|
