EC Number   |
Inhibitors |
Structure |
|---|
    4.1.1.48 | ATB107 |
1-azabicyclo[2.2.2]octan-3-one[4-(phenylamino)-6-(1-piperidinyl)-1,3,5-triazin-2-yl]hydrazone, 0.1 microg/ml minimum inhibitory concentration, potent competitive inhibitor of the substrate 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate |
   |
| 4.1.1.48 | ATB107 |
potent inhibitor |
|
| 4.1.1.48 | geomycine |
0.5 mg/ml |
|
| 4.1.1.48 | H2O2 |
0.001% H2O2 inactivates the enzyme almost completely |
|
| 4.1.1.48 | kanamycin |
0.5 mg/ml |
|
| 4.1.1.48 | L-tryptophan |
tryptophan at high concentrations has definite inhibitory activity against Mycobacterium tuberculosis but does not antagonize the activity of ATB107 |
|
| 4.1.1.48 | methanol |
enzyme activity is gradually lost in the presence of increasing concentrations of methanol and completely lost at 65% |
|
| 4.1.1.48 | more |
inhibitory effect of ATB107 can not be reversed by the addition of tryptophan |
|
| 4.1.1.48 | phosphate |
- |
|
| 4.1.1.48 | Reduced 1-[2-carboxyphenyl)amino]-1-deoxyribulose 5-phosphate |
- |
|
