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Results 1 - 10 of 23 > >>
EC Number Inhibitors Commentary Structure
Show all pathways known for 3.5.4.10Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.102'-deoxy-AMP decreased IMP cyclohydrolase activity by 10-50% Go to the Ligand Summary Page
Show all pathways known for 3.5.4.10Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.102,2-dioxo-1,5-dihydroimidazo[4,5-c][1,2,6]thiadiazin-4(3H)-one construction of 1,5-dihydroimidazo[4,5-c][1,2,6]thiadiazin-4(3H)-one 2,2-dioxide, the corresponding nucleoside, and the nucleoside monophosphate, as mimics of the tetrahedral intermediate in the cyclization reaction. All compounds are competitive inhibitors against IMPCH, but the simpler heterocycle has a completely different IMPCH binding mode, compared to the nucleosides, and is relocated to the phosphate binding pocket, the aromatic imidazole ring interacts with a helix dipole, inhibitor synthesis, binding structure, and mechanism of inhibition, overview Go to the Ligand Summary Page
Show all pathways known for 3.5.4.10Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.102-chloroinosine 5'-monophosphate potent inhibitor Go to the Ligand Summary Page
Show all pathways known for 3.5.4.10Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.102-flouroinosine 5'-monophosphate IC50-value in cell culture 0.0049 mM; potent inhibitor Go to the Ligand Summary Page
Show all pathways known for 3.5.4.10Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.102-fluoroadenine arabinoside 5'-monophosphate IC50-value in cell culture 0.0002 mM; strong competitive inhibitor, derivative of anti-cancer drug Go to the Ligand Summary Page
Show all pathways known for 3.5.4.10Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.102-fluoroadenine arabinoside 5'-monophosphate strong competitive inhibitor, derivative of anti-cancer drug Go to the Ligand Summary Page
Show all pathways known for 3.5.4.10Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.102-mercaptoinosine 5'-monophosphate most potent competitive inhibitor, precursor of GMP in the purine pathway Go to the Ligand Summary Page
Show all pathways known for 3.5.4.10Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.105-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside decreased IMP cyclohydrolase activity by 10-50% Go to the Ligand Summary Page
Show all pathways known for 3.5.4.10Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.106-mercaptopurine riboside 5'-monophosphate IC50-value in cell culture 0.0075 mM; strong competitive inhibitor, derivative of anti-cancer drug Go to the Ligand Summary Page
Show all pathways known for 3.5.4.10Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.106-mercaptopurine riboside 5'-monophosphate strong competitive inhibitor, derivative of anti-cancer drug Go to the Ligand Summary Page
Results 1 - 10 of 23 > >>