EC Number |
Inhibitors |
Structure |
---|
3.4.24.85 | more |
gamma-sectretase inhibitor LY411575 is not inhibitory for enzyme |
|
3.4.24.85 | more |
SpoIVFB is held inactive by two other integral-membrane proteins, SpoIVFA and BofA |
|
3.4.24.85 | 1,10-phenanthroline |
1,10-phenanthroline specifically inhibits substrate cleavage in a concentration-dependent manner |
|
3.4.24.85 | 1,10-phenanthroline |
- |
|
3.4.24.85 | cholesterol |
inhibits the first cleavage of SREBP and indirectly S2P cleavage |
|
3.4.24.85 | nelfinavir |
nelfinavir and its analogs inhibit cleavage of artificial protein substrate CED-9 in an in vitro proteolysis assay. Nelfinavir and its analogs inhibit castration-resistant prostate cancer proliferation by blocking regulated intramembrane proteolysis through suppression of site-2 protease cleavage activity |
|
3.4.24.85 | nelfinavir |
nelfinavir is a more potent inhibitor of CED-9 protein cleavage than 1,10-phenanthroline |
|
3.4.24.85 | BofA protein |
- |
|
3.4.24.85 | 7,8-dimethoxy-1,2,3,11a-tetrahydro-5H,11H-pyrrolo[2,1-c][1,4]benzothiazepine-5,11-dione |
analog of nelfinavir, inhibits cleavage of artificial protein substrate CED-9 in an in vitro proteolysis assay. Inhibits castration-resistant prostate cancer proliferation by blocking regulated intramembrane proteolysis through suppression of site-2 protease cleavage activity |
|
3.4.24.85 | 7,8-dimethoxy-1,2,3,11a-tetrahydro-5H,11H-pyrrolo[2,1-c][1,4]benzothiazepine-5,11-dione |
- |
|