EC Number |
Inhibitors |
Structure |
---|
3.4.23.12 | 4-(2-aminoethyl)benzenesulfonyl fluoride |
about 70% residual activity at 0.1 mM |
|
3.4.23.12 | CoSO4 |
- |
|
3.4.23.12 | CuCl2 |
- |
|
3.4.23.12 | cupric ions |
strong inhibition of nepenthesin I and II by diazoacetyl-DL-norleucine in presence of cupric ions, no inactivation in absence of cupric ions |
|
3.4.23.12 | diazoacetyl-DL-norleucine |
strong inhibition of nepenthesin I and II in presence of cupric ions, no inactivation in absence of cupric ions |
|
3.4.23.12 | Diazoacetyl-DL-norleucine methyl ester |
i.e. DAN |
|
3.4.23.12 | dithiothreitol |
isoforms nethepsin I, IIa and IIb are completely inactivated in the presence of 40-70 mM dithiothreitol |
|
3.4.23.12 | DL-Norleucine methyl ester |
- |
|
3.4.23.12 | DMSO |
about 65% residual activity at 0.1 mM |
|
3.4.23.12 | E-64 |
about 97% residual activity at 0.02 mM |
|