EC Number |
Inhibitors |
Structure |
---|
3.4.22.46 | (2S,3R,4R)-2-{[2-(2,3-dihydroxyphenyl)-5,8-dihydroxy-4-oxo-4H-chromen-7-yl]oxy}-4-hydroxy-4-(hydroxymethyl)tetrahydrofuran-3-yl alpha-D-galactopyranoside |
- |
|
3.4.22.46 | 2-(3,4-dihydroxyphenyl)ethyl 4-O-[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]-6-O-alpha-L-lyxopyranosyl-beta-D-glucopyranoside |
- |
|
3.4.22.46 | CA074 |
epoxide-based inhibitor of cysteine proteinases, two-step overall irreversible inhibition, with step one being reversible and step two irreversible |
|
3.4.22.46 | CA074 |
- |
|
3.4.22.46 | E64 |
epoxide-based inhibitor of cysteine proteinases, two-step overall irreversible inhibition, with step one being reversible and step two irreversible. Extending E64 by addition of the dipeptide R-P to a compound termed E64-R-P-NH2, which irreversibly inhibits Lbpro with a Ki of 30 nM and k4 of 0.01/min, can serve as the basis for design of specific inhibitors of FMDV replication |
|
3.4.22.46 | E64-R-P-NH2 |
extending E64 by addition of the dipeptide R-P to a compound termed E64-R-P-NH2, which irreversibly inhibits Lbpro with a Ki of 30 nM and k4 of 0.01/min, can serve as the basis for design of specific inhibitors of FMDV replication |
|
3.4.22.46 | E64-R-P-NH2 |
- |
|
3.4.22.46 | more |
sensitive to high ionic strength, 50% inactivation by 20 mM NaCl or 10 mM CaCl2 |
|
3.4.22.46 | more |
self-processing inactivates leader proteinase nsp1alpha |
|
3.4.22.46 | trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane |
i.e. E-64 |
|