EC Number   |
Inhibitors |
Structure |
|---|
   3.4.21.93 | dSAAS-(235-244) |
- |
   |
| 3.4.21.93 | more |
starvation reduces the serum levels of leptin which decreases PC1 expression, the effect can be reversed by administration of exogenous leptin |
|
| 3.4.21.93 | more |
hyperthyroidism suppresses enzyme expression in hypothalamus and cerebral cortex |
|
| 3.4.21.93 | more |
proprotein convertase 1/3 expression is reduced in Bon-1 cells overexpressing Pdcd4 |
|
| 3.4.21.93 | more |
in wild-type mice prohormone convertase 1/3 mRNA levels show a 75% reduction with food deprivation and exceed ad libitum-fed levels after leptin treatment. Hypothalamic prohormone convertase 1/3 mRNA levels in N2KO mice show no significant variation between the deprived condition and ad libitum feeding. Leptin-treated N2KO mice have significantly lower prohormone convertase 1/3 mRNA levels than leptin-treated wild-type mice |
|
| 3.4.21.93 | morphine |
human prohormone convertase 1/3 promoter activity is 73.1% in GH3-mu-opioid receptor cells receiving morphine compared with cells receiving media, and this reduction is reversed by naltrexone. In cells transfected with the prohormone convertase 1/3-minusCRE1/2 promoter construct, morphine does not reduce prohormone convertase 1/3-promoter activity. In wild-type GH3 cells (without the mu-opioid receptor), human prohormone convertase 1/3 promoter does not respond to morphine treatment. Regulation of prohormone convertase 1/3 promoter activity by morphine is mediated through the mu-opioid receptor |
|
| 3.4.21.93 | morphine |
short-term morphine (24 h) exposure downregulates prohormone convertase 1/3 protein levels in the rat hypothalamus. The cyclic-AMP response element in the promoter of prohormone convertase 1/3 is required for morphine-induced regulation of prohormone convertase 1/3 |
|
| 3.4.21.93 | PC1 CT peptide |
- |
|
| 3.4.21.93 | PC1 pro-peptide |
inhibits the mature PC1 |
|
| 3.4.21.93 | PC1 propeptide |
- |
|
