EC Number |
Inhibitors |
Structure |
---|
3.4.21.78 | more |
not: inhibitors of either thiol-, metallo- or carboxyl-proteinases |
|
3.4.21.78 | more |
ecotin has no effect |
|
3.4.21.78 | more |
inhibited by the extracellular serpins anti-thrombin III and C1-inhibitor and by the non-serpin inhibitor alpha2-macroglobulin |
|
3.4.21.78 | more |
GzmA-mediated reactive oxygen species production and cell death are impaired in pseudo rho0 cells depleted of mitochondrial DNA. Expression of the K56A-NDUFS3 cleavage site mutant in 293T and K562 cells inhibits GzmA-mediated reactive oxygen species production and cell death |
|
3.4.21.78 | more |
substrate specificity-based screening for potential inhibitors from the intracellular serpin family, no enzyme inhibition by Serpinb6b |
|
3.4.21.78 | more |
substrate specificity-based screening for potential inhibitors from the intracellular serpin family, overview. A lineage-specific increase in enzyme cytotoxic potential has driven cognate inhibitor evolution |
|
3.4.21.78 | more |
histone H4 cleavage is blocked by the GzmA inhibitor nafamostat mesylate and by GzmA knockdown using siRNA. Recombinant histone H4 is treated with trichostatin A, an inhibitor of histone deacetylation, revealing that only untreated histones are digested by GzmA |
|
3.4.21.78 | leupeptin |
- |
|
3.4.21.78 | diisopropyl fluorophosphate |
- |
|
3.4.21.78 | phenylmethylsulfonyl fluoride |
- |
|