EC Number   |
Inhibitors |
Structure |
|---|
   3.1.31.1 | 2'-deoxythymidine 3',5'-diphosphate |
at 100 microM concentration of pdTp, parasites show block in development, most of the parasites appear dead or shrunken within six hours after inhibitor treatment |
   |
| 3.1.31.1 | 3',5'-deoxythymidine diphosphate |
addition to the cell culture medium blocks further growth |
|
| 3.1.31.1 | adenosine 3',5'-diphosphate |
able to induce folding of mutant proteins into the native state |
|
| 3.1.31.1 | Ca2+ |
competitive |
|
| 3.1.31.1 | caspase-3 |
Tudor staphylococcal nuclease, a multifunctional regulator of gene expression, is cleaved by caspase-3 during apoptosis, this cleavage impairs the ability of Tudor staphylococcal nuclease to activate mRNA splicing, inhibits its ribonuclease activity and is important for the execution of apoptosis, cleavage of enzyme lowers its nuclease activity by almost 50% |
|
| 3.1.31.1 | Co2+ |
isozyme Nuc1 shows 79% activity at 5 mM concentration |
|
| 3.1.31.1 | Cu2+ |
competitive |
|
| 3.1.31.1 | deoxythymidine 3',5'-bisphosphate |
nuclease activity of enzyme is highly sensitive to deoxythymidine 3',5'-bisphosphate, a specific inhibitor of staphylococcal nuclease, whereas the inactive analogue deoxythymidine 3'-phosphate has no inhibitory effect |
|
| 3.1.31.1 | deoxythymidine 3',5'-bisphosphate |
nuclease activity of PaTSN is highly sensitive to deoxythymidine 3',5'-bisphosphate, a specific inhibitor of staphylococcal nuclease, whereas the inactive analogue deoxythymidine 3'-phosphate has no inhibitory effect |
|
| 3.1.31.1 | deoxythymidine 3',5'-diphosphate |
in the presence of pdTp, unfolding forces increase drastically |
|
