EC Number   |
Inhibitors |
Structure |
|---|
   3.1.3.64 | Ca2+ |
in the millimolar range, 1 mM: 50-75% inhibition |
   |
| 3.1.3.64 | Mg2+ |
in the millimolar range, slightly less potent than Ca2+ |
|
| 3.1.3.64 | more |
not inhibited by EDTA or EGTA |
|
| 3.1.3.64 | more |
in the presence of myotubularin-related protein 9 , both phosphatidylinositol 4-phosphate and phosphatidylinositol 5-phosphate have an inhibitory effect on myotubularin-related protein 6 activity in 50% phosphatidylserine, the 3-phosphatase activity decreases 30 and 40% for phosphatidylinositol 4-phosphate and phosphatidylinositol 5-phosphate, respectively |
|
| 3.1.3.64 | type III PI3K regulatory subunit hVps15 |
i.e. p150, MTMR2 binding results in inhibition of phosphatase activity and in diminution of hVps34-Rab7 interaction important for PI3P synthesis |
|
| 3.1.3.64 | VO43- |
0.1 mM: 15% inhibition, 0.5 mM: 95% inhibition |
|
| 3.1.3.64 | Zn2+ |
0.5 mM: 90% inhibition |
|
