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EC Number
Inhibitors
Commentary
Structure
3.1.21.5
EDTA
complete inhibition at 0.02 mM
3.1.21.5
HU protein
binding of HU protein interfers with R.EcoP15I cleavage activity
3.1.21.5
Lac repressor
cleavage can be abolished by the binding of Lac repressor downstream (3' side) but not upstream (5' side) of the recognition site
3.1.21.5
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type III restriction is alleviated by bacteriophage (RecE) homologous recombination function
3.1.21.5
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sinefungin neither has an appreciable effect on DNA cleavage by EcoP15I nor compensated for the second recognition site; the catalytic activity of EcoP15I after 3 h of pre-incubation without DNA is strongly decreased
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