EC Number   |
Inhibitors |
Structure |
|---|
   3.1.1.89 | (E)-2-(4-fluorophenylsulfonyl)-3-(1-(3-nitrophenylsulfonyl)-1H-pyrrol-2-yl)acrylonitrile |
compound inhibits PME-1 with more than100fold selectivity relative to other serine hydrolases in human cells. Application reduces the demethylated form of substrate protein phosphatase 2A in living cells |
   |
| 3.1.1.89 | ABL-127 |
- |
|
| 3.1.1.89 | ABL127 |
aza-beta-lactum inhibitor |
|
| 3.1.1.89 | AMZ-30 |
- |
|
| 3.1.1.89 | AMZ30 |
sulfonyl acrylonitrile inhibitor |
|
| 3.1.1.89 | AMZ30 |
PME-1 inhibition by AMZ30 protects against PP2A inactivation and cell apoptosis mediated by alpha-syn |
|
| 3.1.1.89 | dimethyl 3-cyclopentyl-4-oxo-3-phenylcyclobutane-1,2-dicarboxylate |
in both MDA-MB-231 and HEK-293T cells, highly potent and selective inhibition of the enzyme with IC50 values of 11.1 nM and 6.4 nM. Analysis reveals complete and selective in situ inhibition of PME-1 with no activity against more than 50 other serine hydrolases detected in MDA-MB-231 and HEK-293T cells. In both cell lines, inhibition results in significant reductions in the levels of demethylated PP2A |
|
| 3.1.1.89 | DMSO |
- |
|
| 3.1.1.89 | okadaic acid |
- |
|
