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Results 1 - 10 of 96 > >>
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EC Number Inhibitors Commentary Structure
Display the word mapDisplay the reaction diagram Show all sequences 2.7.8.271-methylcyclopropyl 4-(3-((3-((3,5-bis(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)oxy)propyl)piperidine-1-carboxylate inhibitor of isoform SGMS2 with good selectivity against SGMS1 Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.8.271-methylcyclopropyl 4-(3-((3-((3,5-bis(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)oxy)propyl)piperidine-1-carboxylate - Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.8.271-methylcyclopropyl 4-(3-((3-((3,5-bis(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy)propyl)piperidine-1-carboxylate 150fold selectivity for isoform SGMS2 over SGMS1; 150fold selectivity for isoform SGMS2 over SGMS1. The interaction with SGMS2 requires the presence of the amino acids S227 and H229, which are located in the catalytic domain of SMS2 Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.8.271-methylcyclopropyl 4-(3-((3-((3-methoxy-5-(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)oxy)propyl)piperidine-1-carboxylate inhibitor of isoform SGMS2 with good selectivity against SGMS1; potent and selective inhibitor of isoform SGMS2. A repeated treatment in mice leads to significant reduction in hepatic sphingomyelin levels Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.8.271-methylcyclopropyl 4-(3-((3-((3-methoxy-5-(trifluoromethyl)benzyl)(methyl)carbamoyl)-1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl)oxy)propyl)piperidine-1-carboxylate - Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.8.272-((2,5-dichlorobenzyl)oxy)-N-(pyridin-3-yl)benzamide - Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.8.272-((2,5-dimethoxybenzyl)oxy)-N-(pyridin-3-yl)benzamide - Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.8.272-((2,6-dichlorobenzyl)oxy)-N-(pyridin-3-yl)benzamide - Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.8.272-((2,6-dimethylbenzyl)oxy)-N-(pyridin-3-yl)benzamide - Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.7.8.272-((2-((5-chloropentyl)oxy)benzyl)oxy)-N-(pyridin-3-yl)benzamide - Go to the Ligand Summary Page
Results 1 - 10 of 96 > >>
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