EC Number |
Inhibitors |
Structure |
---|
2.7.11.10 | (1R,4R)-4-(2-amino-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-cyclohexanol |
- |
|
2.7.11.10 | (4-([4-(1-benzothiophen-2-yl)pyrimidin-2-yl]amino)phenyl)acetic acid |
IC50 for the IKKbeta is 0.0022 mM |
|
2.7.11.10 | (E)-2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol |
the compound directly binds to the ATP binding site of the enzyme with a strong binding affinity |
|
2.7.11.10 | (E)-4-[3-(5-(adamant-1-yl)-2-(but-1-oxy)-4-(2-methoxyethoxymethoxy)-phenyl)-3-oxoprop-1-en-1-yl]benzoic acid |
shows highest inhibition of IKKbeta and highest induction of apoptosis in Jurkat cells |
|
2.7.11.10 | (E)-4-[3-(5-(adamant-1-yl)-2-(hexyl-1-oxy)-4-(2-methoxyethoxymethoxy)phenyl)-3-oxoprop-1-en-1-yl]benzoic acid |
exhibits improved anti-IKKbeta and growth inhibitory activities and has lost its RAR-dependent transactivation function |
|
2.7.11.10 | (E)-4-[3-(5-(adamant-1-yl)-2-ethoxy-4-(2-methoxyethoxymethoxy)phenyl)-3-oxoprop-1-en-1-yl]benzoic acid |
- |
|
2.7.11.10 | (E)-4-[3-(5-(adamant-1-yl)-4-(2-methoxyethoxymethoxy)-2-(pentyl-1-oxy)phenyl)-3-oxoprop-1-en-1-yl]benzoic acid |
- |
|
2.7.11.10 | (E)-4-[3-(5-(adamant-1-yl)-4-(2-methoxyethoxymethoxy)-2-(prop-2-en-1-oxy)phenyl)-3-oxoprop-1-en-1-yl]benzoic acid |
- |
|
2.7.11.10 | (E)-4-[3-(5-(adamant-1-yl)-4-(2-methoxyethoxymethoxy)-2-(prop-2-yn-1-oxy)phenyl)-3-oxoprop-1-en-1-yl]benzoic acid |
shows highest inhibition of IKKbeta and highest induction of apoptosis in Jurkat cells |
|
2.7.11.10 | (E)-4-[3-(5-(adamant-1-yl)-4-(2-methoxyethoxymethoxy)-2-phenylmethoxy-phenyl)-3-oxoprop-1-en-1-yl]benzoic acid |
exhibits improved anti-IKKbeta and growth inhibitory activities and has lost its RAR-dependent transactivation function |
|