EC Number   |
Inhibitors |
Structure |
|---|
   2.7.1.161 | Co2+ |
1.6 mM, 40% inhibition; 1.6 mM, 61% inhibition |
   |
| 2.7.1.161 | Cu2+ |
1.6 mM, 3% inhibition; 1.6 mM, 97% inhibition |
|
| 2.7.1.161 | Mg2+ |
1.6 mM, 15% inhibition |
|
| 2.7.1.161 | Mn2+ |
1.6 mM, 50% inhibition |
|
| 2.7.1.161 | more |
the FMN-bound enzyme does not show myRbkR concentration-dependent binding with any tested DNA fragment, suggesting that FMN has a disruptive effect on DNA binding |
|
| 2.7.1.161 | more |
FAD does not show any significant effect on enzyme-DNA interaction, while riboflavin and FMN substantially diminish the DNA binding affinity. Half-maximal EC50 of riboflavin and FMN are calculated to 144 nM and 41 nM, respectively, showing that FMN has a greater negative effect on the DNA-protein interactions |
|
| 2.7.1.161 | Ni2+ |
1.6 mM, 43% inhibition; 1.6 mM, 60% inhibition |
|
| 2.7.1.161 | Zn2+ |
1.6 mM, 17% inhibition; 1.6 mM, 83% inhibition |
|
