EC Number |
Inhibitors |
Structure |
---|
2.7.1.138 | (4aR,6aS,12aS,12bR)-10-hydroxy-4,4,6a,12b-tetramethyl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H-benzo(a)xanthene-8,11-dione |
KD, enantiomer of K1, strongly inhibits CerK activity |
|
2.7.1.138 | (4aS,6aR,12aR,12bS)-10-hydroxy-4,4,6a,12b-tetramethyl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H-benzo(a)xanthene-8,11-dione |
K1, non-competitive, suppresses the activation of mast cells, strongly inhibits CerK activity |
|
2.7.1.138 | (4aS,6aR,12aR,12bS)-10-hydroxy-4,4,6a,12b-tetramethyl-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H-benzo(a)xanthene-8,11-dione |
ceramide kinase inhibitor K1, reduces the differences in degranulation observed between the bone marrow-derived mast cells from CERK-/- and wild-type mice in a dose-dependent manner |
|
2.7.1.138 | 1alpha,25-dihydroxyvitamin D3 |
enzyme activity decreases by approximately 40% in the presence of the hormone |
|
2.7.1.138 | 2,5-dihydroxy-3-(((1R,4aR,8aR)-5,5,8a-trimethyl-2-methylidenedecahydronaphthalen-1-yl)methyl)cyclohexa-2,5-diene-1,4-dione |
KB, enantiomer of K1, strongly inhibits CerK activity |
|
2.7.1.138 | 2,5-dihydroxy-3-(((1S,2S,4aS,8aR)-2,5,5,8a-tetramethyldecahydronaphthalen-1-yl)methyl)cyclohexa-2,5-diene-1,4-dione |
KC, F12509A with an additional hydrogen at the double bond in methylene position, weak inhibition |
|
2.7.1.138 | 2,5-dihydroxy-3-(((1S,4aS,8aS)-5,5,8a-trimethyl-2-methylidenedecahydronaphthalen-1-yl)methyl)cyclohexa-2,5-diene-1,4-dione |
F12509A, inhibitor of sphingosine kinase 1, weak inhibition |
|
2.7.1.138 | 2,5-dihydroxy-3-[[(4aS,8aS)-2,5,5,8a-tetramethyl-3,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]methyl]cyclohexa-2,5-diene-1,4-dione |
K1, novel F-12509A olefin isomer, inhibitor decreases ceramide 1-phosphate levels without changing other lipids such as ceramide and sphingomyelin |
|
2.7.1.138 | 3,3-cholamidopropyl-dimethylammonio-1-propanesulfonate |
almost complete inhibition at high concentrations |
|
2.7.1.138 | 3-(cyclohexylmethyl)-2,5-dihydroxycyclohexa-2,5-diene-1,4-dione |
K2, cyclohexane derivative with a benzoquinone, weak inhibition |
|