EC Number |
Inhibitors |
Structure |
---|
2.6.1.85 | (5R,6R)-4-ammonio-5-((1-carboxylatovinyl)oxy)-6-hydroxycyclohex-1-ene-1-carboxylate |
transition-state analogue, competitive |
|
2.6.1.85 | 1-hydroxyphenazine |
inhibitory above 0.200 mM |
|
2.6.1.85 | 2-fluorochorismate |
irreversible, covalent modification of K274 |
|
2.6.1.85 | atrop-abyssomicin C |
- |
|
2.6.1.85 | more |
not inhibited by sulfathiazole |
|
2.6.1.85 | more |
not inhibited by ATP, AMP, dAMP, guanosine, GMP, dGMP, GTP, deoxyguanosine, dTMP, serine, glycine, tyrosine, methionine, p-hydroxybenzoate, PABA, sulfanilamide |
|
2.6.1.85 | more |
enzyme is not regulated by feedback inhibition. Little or no inhibition up to 1 mM: glyphosate, pyridoxamine 5'-phosphate, pyridoxal 5'-phosphate, and 3-hydroxypyridine-4-carboxylic acid |
|
2.6.1.85 | NH3 |
inhibitor of the glutamine amidotransferase reaction (Ki = 5 mM, lowered to 0.27 mM if considered that NH3 and not NH4+ is the true inhibitor (pKa value of 9.24)) |
|
2.6.1.85 | phosphate |
phosphate buffer competitively inhibits PhzE, about 20% inhibition with 100 mM potassium phosphate at pH 7.0 |
|
2.6.1.85 | pyocyanin |
inhibitory above 0.250 mM |
|