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EC Number
Inhibitors
Commentary
Structure
2.5.1.39
2,4-dinitrophenol
16% inhibition at 1 mM
2.5.1.39
4-Aminobenzoic acid
-
2.5.1.39
4-Chlorobenzoic acid
-
2.5.1.39
4-nitrobenzoate
competitive enzyme inhibition, cell treatement with 4-nitrobenzoate leads to a decrease in coenzyme Q content, but 4-nitrobenzoate treatment has no apparent toxic effect on the cells and does not decrease Q concentration by inducing oxidative stress
2.5.1.39
4-nitrobenzoate
inhibition of COQ2 by 4-nitrobenzoate, leading to 40-50% residual CoQ10, is associated with increased oxidative stress and reduced viability, together with moderately decreased ATP levels and ATP/ADP ratio
2.5.1.39
acetyl-CoA
weak
2.5.1.39
Ag+
complete inhibition at 0.1 mM
2.5.1.39
bacitracin
strong inhibitor
2.5.1.39
beta-octyl glucoside
-
2.5.1.39
Brij W1
inhibition at 0.5% or more, activation at 0.05%
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