EC Number   |
Inhibitors |
Structure |
|---|
    2.3.1.230 | (2-nitrophenyl)(phenyl)methanol |
0.05 mM, 99% inhibition |
   |
| 2.3.1.230 | (2-nitrophenyl)(thiophen-3-yl)methanol |
inhibitor shows almost no time-dependency of PqsD inhibition |
|
| 2.3.1.230 | (2R)-2,4-dihydroxy-3,3-dimethyl-N-(3-[[4-(2-nitrophenyl)-4-oxobutyl]amino]-3-oxopropyl)butanamide |
0.05 mM, 18% inhibition |
|
| 2.3.1.230 | (2R)-2,4-dihydroxy-N-(3-[[4-hydroxy-4-(2-nitrophenyl)butyl]amino]-3-oxopropyl)-3,3-dimethylbutanamide |
0.05 mM, 95% inhibition |
|
| 2.3.1.230 | (S)-(2-nitrophenyl)(phenyl)methanol |
most active compound of the series, capable of reducing the HHQ and PQS levels as well as the biofilm volume in Pseudomonas aeruginosa PA14 without affecting cell viability. The (S)-enantiomer has a pronounced entropic binding profile. Docking results show a short hydrogen bond between NO2 and NH of Ser317. The hydroxyl group is involved in different interactions, either facing toward Asn287 or His256/Cys112 |
|
| 2.3.1.230 | 1-(2-nitrophenyl)propan-1-ol |
best inhibitor in the cellular test |
|
| 2.3.1.230 | 1-benzyl-2-nitrobenzene |
0.025 mM, 24% inhibition |
|
| 2.3.1.230 | 1-[methoxy(phenyl)methyl]-2-nitrobenzene |
0.05 mM, 97% inhibition |
|
| 2.3.1.230 | 2-(4-bromo-3-diethylsulfamoylbenzoylamino)benzoate |
- |
|
| 2.3.1.230 | 2-([3-[benzyl(ethyl)sulfamoyl]benzoyl]amino)benzoic acid |
- |
|
