EC Number   |
Inhibitors |
Structure |
|---|
   2.1.1.35 | 5-fluorouracil |
exposure to 5-fluorouracil leads to extensive irreversible TRMT2A-tRNA crosslinking in vivo |
   |
| 2.1.1.35 | 5-Fluorouracil substituted tRNA |
first-order inactivation in the presence of S-adenosyl-L-methionine, potent mechanism-based irreversible inhibition, formation of a stable covalent complex containing enzyme, FUra-tRNA and the methyl group of AdoMet; mechanism of inhibition |
|
| 2.1.1.35 | 5-Fluorouracil substituted tRNA |
potent inhibitor |
|
| 2.1.1.35 | 5-Fluorouracil substituted tRNA |
first-order inactivation in the presence of S-adenosyl-L-methionine, potent mechanism-based irreversible inhibition, formation of a stable covalent complex containing enzyme, FUra-tRNA and the methyl group of AdoMet |
|
| 2.1.1.35 | 5-Fluorouracil substituted tRNA |
- |
|
| 2.1.1.35 | 5-Fluorouracil substituted tRNA |
forms inhibitory stable methylated covalent complex with RUMT |
|
| 2.1.1.35 | DNA analog of the T-stem/loop domain |
DNA analog of the T-stem/loop domain of yeast tRNAPhe composed of d(A,U,G,C) inhibits the methylation of unfractionated methyl-deficient E. coli tRNA, significant inhibition when the concentration of tDNAPheT is twice that of the tRNA |
|
| 2.1.1.35 | ethylthioadenosine |
0.2 mM |
|
| 2.1.1.35 | K+ |
inhibitory in presence of Mg2+ |
|
| 2.1.1.35 | L-ethionine |
selective inhibitor of uracil tRNA methylase, non-competitive to S-adenosyl-L-methionine |
|
