EC Number   |
Inhibitors |
Structure |
|---|
    2.1.1.157 | 4-chloromercuribenzoate |
recombinant enzyme: 23% inhibition at 1.33 mM, completely reversible by 5.3 mM DTT |
   |
| 2.1.1.157 | betaine |
recombinant enzyme: poor inhibition, 71% inhibition at 2 M with sarcosine, and 69% inhibition at 2 M with dimethylglycine, partially reversible by salts KCl and NaCl, overview |
|
| 2.1.1.157 | betaine |
above 1.0 M, no effect on sarcosine N-methyltransferase activity, 35% inhibition of N,N-dimethylglycine N-methyltransferase activity |
|
| 2.1.1.157 | betaine |
does not affect the SMT activity, but represses the DMT activity by 35% at 2 M |
|
| 2.1.1.157 | dimethylglycine |
competitive inhibition, versus sarcosine, 40% inhibition at 250 mM |
|
| 2.1.1.157 | isovaleric acid |
10% inhibition at 250 mM, with dimethylglycine |
|
| 2.1.1.157 | KCl/NaCl |
recombinant enzyme: 32% inhibition at 0.33 M KCl and 0.66 M NaCl with sarcosine, and 25% inhibition at 0.33 M KCl and 0.66 M NaCl with dimethylglycine, decrease inhibition by betaine, overview |
|
| 2.1.1.157 | L-alanine |
10% inhibition at 250 mM, with dimethylglycine |
|
| 2.1.1.157 | L-cysteine |
10% inhibition at 250 mM, with dimethylglycine |
|
| 2.1.1.157 | L-methionine |
10% inhibition at 250 mM, with dimethylglycine |
|
