EC Number   |
Inhibitors |
Structure |
|---|
   1.8.4.10 | 2-[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-[(2-sulfanylethyl)amino]-9H-purin-9-yl]oxolan-2-yl]ethyl phosphate |
best inhibitor analyzed. The S atom is capable of establishing favorable interactions with the Fe-S cluster |
   |
| 1.8.4.10 | 5'-AMP |
competitive vs. adenosine-5'-phosphosulfate |
|
| 1.8.4.10 | 5'-AMP |
- |
|
| 1.8.4.10 | adenosine-5'-phosphosulfate |
- |
|
| 1.8.4.10 | more |
not inhibited by 3'-AMP |
|
| 1.8.4.10 | more |
development of a roadmap for rational design of small molecules as potential inhibitors of APS reductase |
|
| 1.8.4.10 | more |
analysis of inhibitors and molecular docking shows a clearly defined spacing requirement between the Fe-S targeting group and adenosine scaffold. Smaller Fe-S targeting groups are better tolerated. The S atom of the most potent inhibitor may establish a favorable interaction with an S atom in the cluster |
|
